Four of the top six on the men's tour have skipped Miami, and with the exit of the Russian top seed on Wednesday there are no players with a Masters 1000 title left in the draw. Medvedev, who replaced Rafa Nadal as No. 2 last month, went into the quarter-final with a 17-2 win-loss record for the season but had lost to the experienced Spaniard in their two previous career meetings.

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